FIRST LOOK: Signaling and Pulmonary Vascular Disease

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Our laboratory has investigated the role of bone morphogenetic protein (BMP) and transforming growth factor β (TGF-β) signaling pathways in the pathogenesis of vascular disease. Loss-of-function mutations involving this pathway are implicated in several congenital vascular syndromes including heritable pulmonary arterial hypertension (HPAH) and hereditary hemorrhagic telangiectasia (HHT) syndrome. A physiologic balance of BMP, Activin,…

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