Mass General Brigham Innovation Discovery Grants Program

Background and Purpose

The Innovation Discovery Grants (IDG) program aims to enhance the commercial outcomes of the Mass General Brigham community and increase its innovative potential. It is designed to stimulate new inventive concepts, identify areas of commercially significant scientific strength and accelerate commercialization of Mass General Brigham intellectual assets.

Areas of Interest

In 2022, the IDG funding opportunity is open to all clinical areas and technology types. The IDG program will fund projects that can demonstrate tangible outcomes towards commercialization licensing opportunities, or a spinoff company, that improves patient health.

Key Dates and Information

  • Pre-proposals are due no later than October 26, 2021, 11:59pm EST.
  • Full proposals will be invited by December 17, 2021.
  • Full proposals will be due February 1, 2022, 11:59pm EST.
  • Awards will be announced at the World Medical Innovation Forum in May, 2022.
  • The earliest possible start date is June 1st, 2022.
  • Projects may request up to $100,000 total cost (inclusive of 15% indirect costs).
  • Project plans must demonstrate tangible outcomes towards commercialization opportunities that improve patient health or healthcare delivery.
  • Guidelines and further information are available on the opportunity website: https://idg.partners.org/prog/mass_general_brigham_innovation_discovery_grants_idg_/

Intellectual Property

Awards will be governed by the Mass General Brigham Intellectual Property Policy. External pharma and device companies will be actively involved during the review process.

Do not include unprotected proprietary information in your application. Questions related to intellectual property and confidentiality should be directed to your Mass General Brigham Innovation Licensing Manager at 857-307-2400.

Additional information

Questions related to IDG grants policies or procedures should be directed Lesley Watts, Director of Sponsored Programs at lwatts@partners.org / 857-307-2440. Questions related to the business opportunity should be directed to your Mass General Brigham Innovation Licensing Manager or Market Sector Leader at 857-307-2440.

2021 Innovation Discovery Grants

Six game-changing technologies targeted at disease areas ranging from treatment of autoimmunity, to cancer, glaucoma to receive funding and Bayer mentoring.

Innovation Discovery Grants Winners

BH | Brigham and Women's Hospital
MGH | Massachusetts General Hospital
HMS | Harvard Medical School
MEE | Massachusetts Eye and Ear
NWH | Newton-Wellesley Hospital

2021

Generating Superior 'Killers' for Adoptive Cell Therapy in Cancer

Lydia Lynch, PhD
Brigham and Women's Hospital

 

Novel Strategies to Enhance Tfr Treatment of Autoimmunity

Peter Sage, PhD
Brigham and Women's Hospital

 

Long-Lasting mRNA Therapy for Genetic Disorders

Jinjun Shi, PhD
Brigham and Women's Hospital

 

AAV-Based Gene Replacement Therapy Improves Targeting and Clinical Outcomes in a Childhood CNS Disorder

Yulia Grishchuk, PhD
Massachusetts Eye and Ear

 

Towards a Permanent Genetic Cure for Spinal Muscular Atrophy

Benjamin Kleinstiver, PhD
Massachusetts General Hospital

 

Differentiation of Retinal Neurons for Cell Replacement in Glaucoma

Petr Baranov, MD, PhD
Massachusetts Eye and Ear

2020

Brain Penetrant AAV Vectors for CNS Gene Therapy

Fengfeng Bei, PhD
Brigham and Women’s Hospital

 

Commensal Papillomavirus Vaccine Development for Skin Cancer Therapy

Shawn Demehri, MD, PhD
Massachusetts General Hospital

 

Harnessing Neutrophil Plasticity for the Treatment of Cancer

Tanya Mayadas, PhD
Brigham and Women's Hospital

 

A Clinically Applicable AI Toolbox for Dystonia Diagnosis

Kristina Simonyan, MD, PhD
Massachusetts Eye and Ear

 

Down Syndrome Clinic to You (DSC2U)

Brian Skotko, MD
Massachusetts General Hospital

 

Addressing the Need for Early, Accurate Diagnosis of Parkinson’s Disease: A New PET Radiotracer

Anna Sromek, PhD
McLean Hospital

2019

Computational and experimental deconvolution of circulating exosomal signals in melanoma immunotherapy patients

Genevieve Boland, MD, PhD
Massachusetts General Hospital
Assistant Professor of Surgery, Surgery, MGH

 

Embryo assessment and selection using artificial intelligence

Charles Bormann, PhD
Massachusetts General Hospital
IVF Laboratory Director, MGH; Instructor, HMS

 

A generalizable artificial intelligence platform for brain cancer frozen section diagnosis

Jeffrey Golden, MD
Brigham and Women's Hospital
Chair, Department of Pathology, BH; Ramzi S. Cotran Professor of Pathology, HMS

 

Making the 'invisible' visible: bringing intimate partner violence into focus

Bharti Khurana, MD
Brigham and Women's Hospital
Director, Emergency Musculoskeletal Radiology, BH; Assistant Professor, HMS

 

Developing a novel machine learning algorithm to automate drug infusions in the operating room and ICU

Vesela Kovacheva, MD, PhD
Brigham and Women's Hospital
Attending Anesthesiologist, BH; Instructor, Anesthesiology, HMS

 

Artificial Intelligence Diffraction Analysis (AIDA)

Hakho Lee, PhD
Massachusetts General Hospital
Hostetter MGH Research Scholar, MGH; Associate Professor, Radiology, HMS

 

Virtual biopsy of brain injury: deep learning to identify diagnostic metabolic biomarkers

Alexander Lin, PhD
Brigham and Women's Hospital
Director, Center for Clinical Spectroscopy, BH; Assistant Professor, Radiology, HMS

 

Automatic cerebral lesion detection and disease progression in patients with Adrenoleukodystrophy (ALD)

Patricia Musolino, MD, PhD
Massachusetts General Hospital
Co-Director Pediatric Cerebrovascular Service, MGH; Assistant of Neurology, HMS

 

Disease-specific testing of an artificial intelligence system for tight blood pressure control

Andrew Reisner, MD
Massachusetts General Hospital
Director, Clinical Decision Technology Laboratory, MGH; Associate Professor, Emergency Medicine, HMS

 

Live pilot test of an artificial intelligence system for trauma care decision-support

Andrew Reisner, MD
Massachusetts General Hospital
Director, Clinical Decision Technology Laboratory, MGH; Associate Professor, Emergency Medicine, HMS

 

Finding needles in the haystack, using machine learning and natural language processing to identify patients and track disease progression

Li Zhou, MD, PhD
Brigham and Women's Hospital
Associate Professor/Lead Investigator, BH; Associate Professor, HMS

2018

Using deep learning to predict next-day patient discharges to optimize hospital capacity management

Peter Dunn, MD
Massachusetts General Hospital
Vice President, Perioperative Services and Healthcare System Engineering, MGH; Assistant Professor, Anesthesia, HMS

 

A web-based neural network calculator for ovarian cancer screening using serum miRNA

Kevin Elias, MD
Brigham and Women's Hospital
Director, Gynecologic Oncology Research Laboratory, BH; Assistant Professor, HMS

 

Machine learning for optimized intraoperative multiplexed quantitative optical image guidance for brain tumor surgery

Alexandra Golby, MD
Brigham and Women's Hospital
Director, Image-Guided Neurosurgery, BH; Professor, Neurosurgery, Radiology, HMS

 

DeepROP - a point-of-care system for diagnosis of plus disease in retinopathy of prematurity

Jayashree Kalpathy-Cramer, PhD
Massachusetts General Hospital
Director, QTIM Lab, MGH; Associate Professor, Radiology, HMS

 

Breast cancer scanning initiative: predicting unnecessary surgeries in high-risk-breast lesions

Jochen Lennerz, MD, PhD
Massachusetts General Hospital
Associate Director, Center for Integrated Diagnostics, MGH; Assistant Professor, HMS

 

Ultrasound-based sensors for physiological monitoring and how they can make MRI and PET/CT scanners work better

Bruno Madore, PhD
Brigham and Women's Hospital
Associate Professor, Radiology, BH, HMS

 

Augmented digital microscopy for diagnosis of endometrial neoplasia

George Mutter, MD
Brigham and Women's Hospital
Medical Director, Reproductive Endocrinology Laboratory, BH, Professor of Pathology, HMS

 

Deep-learning facilitated lesion detection in medical images

Jinsong Ouyang, PhD
Massachusetts General Hospital
Physicist, MGH; Associate Professor, HMS

 

Poly-exposure risk scores for psychiatric disorders

Martin Teicher, MD, PhD
McLean Hospital
Director, Developmental Biopsychiatry Research Program, McLean; Associate Professor, Psychiatry, HMS

 

Development of a machine learning algorithm-guided approach to treatment selection for depressed patients

Christian Webb, PhD
McLean Hospital
Director, Treatment and Etiology of Depression, Youth Lab, McLean; Assistant Professor, Psychiatry, HMS

 

Artificial intelligence based seizure detection and classification

Brandon Westover, MD, PhD
Massachusetts General Hospital
Executive Director, Clinical Data Animation Center, MGH; Associate Professor, Neurology, HMS

 

The identification of intracranial hemorrhage using machine-learning analysis of sparse transcranial ultrasound signals

Philip White, PhD
Brigham and Women's Hospital
Assistant Professor, Radiology, BH, HMS

2016

Scar-free fractional microbiopsy

W. Gerald (Jay) Austen, MD
Massachusetts General Hospital
Edward D. Churchill Distinguished Professor of Surgery, Surgery, MGH

 

Therapeutic microbiota in food allergy

Lynn Bry, MD, PhD
Brigham and Women's Hospital
Associate Professor of Pathology, Pathology, BH

 

A noninvasive optical monitoring device system for diagnosis & quantitative monitoring of peripheral artery dysfunction

Blaise Frederick, PhD
McLean Hospital
Associate Professor of Psychiatry, Psychiatry, McLean

 

Long-acting oxytocin formulation for treatment of obesity

Elizabeth Lawson, MD
Massachusetts General Hospital
Associate Professor of Medicine, Medicine, MGH

 

Gene therapy platform for the treatment of inherited deafness

Casey Maguire, PhD
Massachusetts General Hospital
Associate Professor of Neurology, Neurology, MGH

 

Development of long-acting PTH analogs for treatment of hypoparathyroidism

Michael Mannstadt, MD
Massachusetts General Hospital
Associate Professor of Medicine, Medicine, MGH

 

Granulocyte progenitor transfusions for the treatment of patients with neutropenia

Michael Mansour, MD, PhD
Massachusetts General Hospital
Assistant Professor of Medicine, Medicine, MGH

 

EveryBaby: wireless heart rate sensor for feedback during newborn resuscitation

Kristian Olson, MD
Massachusetts General Hospital
Associate Professor of Medicine, Medicine, MGH

 

SMOC2: a novel therapeutic target for kidney fibrosis

Vishal Vaidya, PhD
Brigham and Women's Hospital
Associate Professor of Medicine, Part-time, Medicine, BH

 

Anti-LAP antibody: a new checkpoint inhibitor for the treatment of cancer

Howard Weiner, MD
Brigham and Women's Hospital
Robert L. Kroc Professor of Neurology, Neurology, BH

2014

Treatment of vein graft disease by suprpressing Dll4-notch signaling

Masanori Aikawa, MD, PhD
Brigham and Women's Hospital
Yoshihiro Miwa Associate Chair and Founding Director, Center for Interdisciplinary Cardiovascular Sciences, BH

 

Novel approach for prevention of vein graft intimal hyperplasia

W. Gerald (Jay) Austen, MD
Massachusetts General Hospital
Edward D. Churchill Distinguished Professor of Surgery, Surgery, MGH

 

Knee range of motion monitoring device

Paolo Bonato, PhD
Spaulding Rehabilitation Hospital
Assoicate Professor of Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation, SRH

 

Novel treatment for kidney diseases

Joseph Bonventre, MD, PhD
Brigham and Women's Hospital
Samuel A. Levine Distinguished Professor of Medicine, Medicine, BH

 

Novel non-invasive markers of early inflammation in the kidney

Sylvie Breton, PhD
Massachusetts General Hospital
Professor of Medicine, Emerita, Emeritus, MGH

 

Noninvasive imaging of fibrinogenesis

Peter Caravan, PhD
Massachusetts General Hospital
Professor of Radiology, Radiology, MGH

 

Treatment for ovarian cancer

Patricia K. Donahoe, MD
Massachusetts General Hospital
Marshall K Bartlett Distinguished Professor of Surgery, Surgery, MGH

 

Reducing healthcare utilization in pulmonary embolism

Raul San Jose Estepar, PhD
Brigham and Women's Hospital
Co-Director, Applied Chest Imaging Laboratory, BWH; Associate Professor, Radiology, HMS

 

Treatment of liver disease with a GLP-a fragment

Joel Habener, MD
Massachusetts General Hospital
Professor of Medicine, Medicine, MGH

 

Targeting the gut to prevent the metabolic syndrome

Richard Hodin, MD
Massachusetts General Hospital
Professor of Surgery, Surgery, MGH

 

Rapid diagnostic for infectious diseases

Deborah Tan Hung, MD, PhD
Massachusetts General Hospital
Professor of Genetics, Genetics, MGH; Associate Professor of Medicine, Medicine, BH

 

Fogarty style balloon-tipped epidural catheter

Ronald Hurley, MD
Brigham and Women's Hospital
Anesthesia, BH

 

IDG portable magnetic resonance device for the pulmonary ICU

Samuel Patz, PhD
Brigham and Women's Hospital
Professor of Radiology, Radiology, BH

 

High throughput sequencing to identify novel vaccine antigens

Gerald Pier, PhD
Brigham and Women's Hospital
(Gerald Bryan Pier), Professor of Medicine (Microbiology and Molecular Genetics), Medicine, BH

 

Sensors for pediatric anesthetic monitoring

Patrick Lee Purdon, PhD
Massachusetts General Hospital
Associate Professor of Anesthesia, Anesthesia, MGH

 

A device for low field magnetic stimulation

Michael Rohan, PhD
McLean Hospital
Lecturer on Psychiatry, Psychiatry, McLean

 

Highly accurate freehand volumetric ultrasound device

Anthony Samir, MD
Massachusetts General Hospital
Assistant Professor of Radiology, Radiology, MGH

 

Nonsurgical alternatives to gastric bypass for treatment of type 2 diabetes

Ali Tavakkoli, MD, MB, BS
Brigham and Women's Hospital
Associate Professor of Surgery, Surgery, BH

 

Development of hemopexin as prophylaxis for hem-related pathology in premature infants

H. Shaw Warren, MD
Massachusetts General Hospital
Associate Professor of Pediatrics, Pediatrics, MGH

 

New generation micro dissection for rapid molecular testing

Yukako Yagi, PhD
Massachusetts General Hospital
Research Fellow, Genetics, MGH